Barrett’s esophagus: lessons from recent clinical trials
نویسندگان
چکیده
Data from recent studies cast doubt on former recommendations on diagnosis and management of Barrett's esophagus. Based on latest research findings several Gastroenterological Associations actualized their guidelines and international experts compiled consensus statements as practical help for clinicians. In this review we discuss recent trials and their impact on clinical practice, current recommendations and persisting controversies in Barrett's esophagus.
منابع مشابه
CCR New Strategies New Strategies in Barrett's Esophagus: Integrating Clonal Evolutionary Theory with Clinical Management
Barrett’s esophagus is a condition in which the normal stratified squamous epithelium of the distal esophagus is replaced by intestinal metaplasia. For more than three decades, the prevailing clinical paradigm has been that Barrett’s esophagus is a complication of symptomatic reflux disease that predisposes to esophageal adenocarcinoma. However, no clinical strategy for cancer prevention or ear...
متن کاملMetaplasia in Barrett’s esophagus: A specific phenotype?
Barrett’s esophagus (or columnar epithelium lined lower esophagus (CELLO) or “endobrachyoesophage” in French) is an acquired condition in which the squamous epithelium of the lower esophagus is replaced by a metaplastic glandular epithelium (1). Barrett’s esophagus represents an abnormal healing of esophageal ulceration usually secondary to severe gastroesophageal reflux disease. Although the c...
متن کاملBarrett's esophagus and antireflux surgery: wraps, rings, and HALOs.
To the Editor: W e read with interest the article by Reveiller et al,1 which was published in a recent issue of the Annals of Surgery. The genetic studies compared the effects of bile and acid on squamous and columnar epithelial cells of the esophagus, thus remodeling gastroesophageal reflux disease at the cellular level. The authors found that the major compounds of reflux, that is, bile and a...
متن کاملThe problems with surveillance of Barrett's esophagus.
In patients with Barrett’s esophagus, the native squamous epithelium of the esophagus is replaced by metaplastic columnar epithelium that is subject to dysplasia and mutation into esophageal adenocarcinoma. The incidence of esophageal adenocarcinoma, a particularly lethal form of cancer, increased by a factor of 6 in the United States between 1975 and 2001.1 Identified risk factors for esophage...
متن کاملBARRETT’S ESOPHAGUS AND ASSOCIATED ADENOCARCINOMA - Studies on pathogenesis, clinical staging, and cost-utility of cancer treatment
.................................................................................................................... 8 INTRODUCTION ......................................................................................................... 10 REVIEW OF THE LITERATURE ................................................................................. 12 1. Barrett’s esophagus ..........................
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 29 شماره
صفحات -
تاریخ انتشار 2016